Direction-For-Live-Combined-Bifidobacterium-and-Lactobacillus-Tablets.docx

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1、DirectionFor1.iveCombinedBiridobacteriumand1.actobacillusTabletsDrugNametGeneralName：1.iveCombinedBidobactcriumand1.actobacillus,!ab!cts.TradeNamesGoldenBifidIngredient：BitidobactcriumIongum,IVaCtobaCiHUEbulgaricusandStreptococcusthermophilus.ThroeactiveComponentswen:producedbyUSaccordingIUauthorize

2、dmanufacturePIXxredUrVandidentifyPlWCdUNDcscriptioniMilkywhileorlightyellowtablet,allendbyyellowspeckle.IndicationstGoldenBiGdismainlyusedinthetreatmemofdiarrheawhichisdueobacteriagroupoutofbalance.Ofchronicdiarrhea,ofCOnStiPaIiCnrdiarrtwaWhiChisunavailingbytheIrealmentofHnlib心IiCSdrug.Speci11cation

3、O.5gtablet,nolesshanfiftymillionlivingBifidobacterium,fivemillionliving1.actobacillusbulgaricusandStrCPtOCoeCUSthermophilusAdministrationandDsagetOrally,four(abletseachtime*(woorthreedinesdaily.TakemedicineWithwarm,waterorwarm.milk.AdversercactionNoadversercaclionPointforattentionColdstorage.Sealupf

4、orsafekeepinginvacuum*Pleaselakeitassoonaspossibleafteropeningthepack.EarlvchildhdtOrally.EarlyChikIhoodofsixmonths,onetableteachdme.twoorthreelimesdaily：Sixnnhs(othreeyearsold.wotabletseachtiinetwoorthreelimesdaily：threeyearstotwelveyearsoldthreetabletseachtime,twoorthreetimesdaily.Takemedicinewith

5、warm-waterorwarm-milk.Babytakescrushedmedicinewithwa11n-milk.Elderlypatients：Indiscriminationwithadult.DrugjjeryreciprocityiThisproductisSUSCCPtiblCtoBcnzylpeni,cillin.Ampicillinsodium.Clindamycinhydrochloride*Cephalothin.Staggernedicationhours.OverdosagetDuringmousetoxicityexperiment.5.O5.5gdrugpow

6、derwasperfusedintostomachofamouseperkilogrammeavoirdupois,dosesis50limesofadulsobserveforI4daysinrow.diMMaion.pathologicsliceOfhCanliver,spleen,kidneyarcmuchthesame.PharnuicokineticstTlireekindsOfbaeteriawhichareBifidobacteriumIongum.1.actobacillusbulgaricusandScrcpiocOCCBSthermophilusarcnormalphysi

7、ologicalbacteriagroupsinintestinesOflhehealthyhuman.TheycangnwandIVProdlKXinhumanintestines.Storage：Keepiin28C，darkanddryplace.双岐杆菌乳杆菌三联活菌片说明书【药品名称】通用名称：双歧杆菌乳杆菌三联活菌片商品名称：金双歧英文名称：1ivccombinedBifidobae,ler。IUmand1.actobacillustablets汉语拼音：ShuangqiganjunRuganjunSanlianHuojunplan【成份】长型双歧杆菌、保加利亚乳杆菌和嗜热链球菌。

8、三种活性成份均按批准的制造及检定规程自行生产得到。【性状】本品为乳白色或微黄色片剂，间有黄色色斑。【适应症】用于治疗肠道菌群失调引起的腹泻、慢性腹泻、抗生.素治疗无效的腹泻及便秘。【规格】0.5克/片，每片含长双歧杆菌活菌应不低于0.5X10cFu,保加利亚乳杆菌和嗜热链球菌活菌均应不低/0.5xl0.,CFU.【用法用量】口服，一次4片，一日23次。温开水或温牛奶冲服“【留意事项】1.相宜于冷藏保存。2.本品真空封装，开袋后应尽快服用。【儿童用药】口服，6个月内樱儿一次1片，一日23次：6个月至3岁小儿一次2片，一日2-3次；3岁至12岁小儿一次3片，一日23次。温开水或温牛奶冲服，婴幼儿可

9、聘药片碾碎后溶于温牛奶冲服。【老年用药】与成人无差异.【药物相互作用】本品对音寄崇、氨甘青宾素、氯洁福素,先锋霉素等敏感，犹如时运用请错开用药时间。【药物过量】在小鼠毒性试验中，小鼠经灌目给药/kg体重，剂量约是成人的50倍。连续视察14天，未见毒性反应。【药理毒理】药理作用：本品可干脆补充人体正常生理细菌，调整肠道曲群平衡，抑制并清除肠道中对人具有潜在危害的细菌.毒理作用：取健康昆明种小鼠60只，体重8-22g,雌雄各半，随机分成2组,每天经口灌胃给药1次,绐药组赐予本品稀锋液0.3ml,剂量相当口服本品g/kg体重，空白比照组赐予等量生理盐水，连续视察14天，并在试验过程中的第3天、第7天、第14天活杀小鼠做病理切片。试验结果表明：本品口服给药剂量为g/kg体歪时，与空白比照组相比，视察至14天小鼠无不良反应，心、肝、脾、肺、肾病理切片无改变。【药代动力学】本品所含三种菌，长型双歧杆菌、保加利亚乳杆菌和嗜热链球菌，皆为健康人肠道正常菌群，可在人体肠道中生长、繁殖。【贮藏】2-8C避光于燥处保存。毕业论文08届石河子高校成人药剂学大专班姓名：李红梅