mFOLFOX6方案与PF方案同步放疗治疗非手术食管癌的近期疗效观察.docx
mFOLFOX6方案与PF方案同步放疗治疗非手术食管癌的近期疗效视察mF0LF0X6方案与PF方案同步放疗治疗非手术食管癌的近期疗效视察【摘要】目的封比非手术食管癌患者实行mF0LF0X6方案同步放化疗与传统PF方案同步放化疗的疗效差异。方法60例H/III期非手术食管鳞癌患者，随机分为试验组(27例)和比照组(33例)。两组均接受三维适形放疗(3D-CRT)。试验组放疗期间予以mF0LF0X6方案同步化疗，比照组放疗期间予以PF方案同步化疗。分析两组近期疗效、治疗毒性反应。结果试验组近期总有效率为92.59%,高于比照组的75.76%,但差异无统计学意义(PO.05)o两组主要毒性为骨髓抑制、消化道反应及神经毒性反应。骨髓抑制主要表现为白细胞削减，其中试验组mw度骨髓抑制发生率为22.2%(6/27),比照组为27.3%(9/33),比较差异无统计学意义(P0.05)。消化道反应主要表现为放射性食管炎、恶心、呕吐。两组均未发生HI度以上食管炎；试验组恶心、呕吐发生率29.6%(8/27)比照组为60.6%(20/33),比较差异有统计学意义(P=0.0170.05)o两组外周神经毒性均为轻度，试验组发生率为66.7%(18/27),比照组为57.6%(19/33),比较差异无统计学意义(PO.05)。全部不良反应经对症治疗后均可缓解，患者能良好耐受。结论与传统PF方案同步放化疗比较，mF0LF0X6方案同步放化疗治疗非手术mF0LF0X6方案与PF方案同步放疗治疗非手术食管癌的近期疗效视察【摘要】目的封比非手术食管癌患者实行mFOLFOX6方案同步放化疗与传统PF方案同步放化疗的疗效差异。方法60例II/III期非手术食管鳞癌患者，随机分为试验组(27例)和比照组(33例)。两组均接受三维适形放疗(3D-CRT)。试验组放疗期间予以mFOLFOX6方案同步化疗，比照组放疗期间予以PF方案同步化疗。分析两组近期疗效、治疗毒性反应。结果试验组近期总有效率为92.59%,高于比照组的75.76%,但差异无统计学意义(PO.05)o两组主要毒性为骨髓抑制、消化道反应及神经毒性反应。骨髓抑制主要表现为白细胞削减，其中试验组mIV度骨髓抑制发生率为22.2%(6/27),比照组为27.3%(9/33),比较差异无统计学意义(P0.05)。消化道反应主要表现为放射性食管炎、恶心、呕吐。两组均未发生m度以上食管炎；试验组恶心、呕吐发生率29.6%(8/27)比照组为60.6%(20/33),比较差异有统计学意义(P=0.0170.05)o两组外周神经毒性均为轻度，试验组发生率为66.7%(18/27),比照组为57.6%(19/33),比较差异无统计学意义(PO.05)o全部不良反应经对症治疗后均可缓解，患者能良好耐受。结论与传统PF方案同步放化疗比较，mFOLFOX6方案同步放化疗治疗非手术食管鳞癌患者近期总有效率较高，近期疗效好，不良反应可耐受，值得进一步探讨。【关键词】非手术食管癌；同步放化疗；mF0LF0X6方案；PF方案D0I：10.14163/jki.ll-5547/r.2023.08.012AbstractObjectiveTocomparedifferenceofcurativeeffectsbetweenmF0LF0X6regimenradiochemotherapyandPFregimeninconcurrentradiochemotherapyfornon-operativeesophaguscancerpatients.MethodsAtotalofstageII11Inon-operativeesophagussquamouscarcinomapatientswererandomlydividedintoexperimentalgroup(27cases)andcontrolgroup(33cases).Bothgroupsreceivedthree-dimensionalconformalradiationtherapy(3D-CRT).TheexperimentalgroupreceivedmF0LF0X6regimenradiOchemotherapyintreatment,andthecontrolgroupreceivedPFregimeninconcurrentradiochemotherapyinstead.Analysiswasmadeonshort-termcurativeeffectandtoxicreactionsintreatmentinthetwogroups.ResultsTheexperimentalgrouphadhighershort-termtotaleffectiverateas92.59%than75.76%inthecontrolgroup,whiIetheirdifferencehadnostatisticalsignificance(PO.05).Maintoxic食管鳞癌患者近期总有效率较高，近期疗效好，不良反应可耐受，值得进一步探讨。【关键词】非手术食管癌；同步放化疗；mF0LF0X6方案；PF方案D0I：10.14163/jki.11-5547r.2023.08.012AbstractObjectiveTocomparedifferenceofcurativeeffectsbetweenmF0LF0X6regimenradiochemotherapyandPFregimeninconcurrentradiochemotherapyfornon-operativeesophaguscancerpatients.MethodsAtotalofstageII11Inon-operativeesophagussquamouscarcinomapatientswererandomlydividedintoexperimentalgroup(27cases)andcontrolgroup(33cases).Bothgroupsreceivedthree-dimensionalconformalradiationtherapy(3D-CRT).TheexperimentalgroupreceivedmF0LF0X6regimenradiOchemotherapyintreatment,andthecontrolgroupreceivedPFregimeninconcurrentradiochemotherapyinstead.Analysiswasmadeonshort-termcurativeeffectandtoxicreactionsintreatmentinthetwogroups.ResultsTheexperimentalgrouphadhighershort-termtotaleffectiverateas92.59%than75.76%inthecontrolgroup,whiIetheirdifferencehadnostatisticalsignificance(PO.05).Main toxic reactions in bothgroupsincludedmyelOsuppression,gastrointestinalreactionsandneurotoxicreactions,withleucopeniaasthemainmanifestationinmyelosuppression.Theexperimentalgrouphadincidenceofgrade11IIVmyelosuppressionas22.2%(6/27),whichwas27.3%(9/33)inthecontrolgroup,andthedifferencehadnostatisticalsignificance(PO.05).Mainmanifestationsofgastrointestinalreactionsincludedradiationesophagitis,nauseaandemesis.TherewasnocasewithoesophagitisovergradeIIIinthetwogroups.Theexperimentalgrouphadincidenceofnauseaandemesisas29.6%(8/27),whichwas60.6%(20/33)inthecontrolgroup,andtheirdifferencehadstatisticalsignificance(P=0.0170.05).Bothgroupshadmildperipheralneurotoxicity,andtheexperimentalgrouphaditsincidenceas66.7%(18/27),whichwas57.6%(19/33)inthecontrolgroup.Theirdifferencehadnostatisticalsignificance(PO.05).Symptomatictreatmentshowedremissioninal1adversereactions,alongwithgoodtoleranceinpatients.ConclusionComparingtraditionalPFregimeninconcurrentradiochemotherapy,mF0LF0X6regimenradiochemotherapyprovideshighShort-termtotalreactionsinbothgroupsincludedmyelosuppression,gastrointestinalreactionsandneurotoxicreactions,withleucopeniaasthemainmanifestationinmyeIosuppression.TheexperimentalgrouphadincidenceofgradeIIIIVmyeIosuppressionas22.2%(6/27),whichwas27.3%(9/33)inthecontrolgroup,andthedifferencehadnostatisticalsignificance(PO.05).Mainmanifestationsofgastrointestinalreactionsincludedradiationesophagitis,nauseaandemesis.TherewasnocasewithoesophagitisovergradeIIIinthetwogroups.Theexperimentalgrouphadincidenceofnauseaandemesisas29.6%(8/27),whichwas60.6%(20/33)inthecontrolgroup,andtheirdifferencehadstatisticalsignificance(P=0.0170.05).Bothgroupshadmildperipheralneurotoxicity,andtheexperimentalgrouphaditsincidenceas66.7%(18/27),whichwas57.6%(19/33)inthecontrolgroup.Theirdifferencehadnostatisticalsignificance(PO.05),Symptomatictreatmentshowedremissioninalladversereactions,alongwithgoodtoleranceinpatient
