A risk assessment of MERS-CoV compared to SARS-CoV.docx
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A risk assessment of MERS-CoV compared to SARS-CoV.docx
AriskassessmentofMERS-CoVcomparedtoSARS-CoVAriskassessmentofMERS-CoVcomparedtoSARS-CoVAriskassessmentofMERS-CoVcomparedtoSARS-CoVMaartjevanGeenen(9756000)SupervisedbyDr.B.J.Boschisecondreviewer:Dr.R.J.deGrootbstractThIscenturytwonoveIcoronaviruseSappearedwithinadecade,Causingbothsevererespiratorydiseaseinhumans.Thesevereacuterespiratorysyndromecoronavirus(SARS-CoV),whichoriginatedinChinainNovember2002,wasthefirstcoronavirustOcauseapandemicinhmansthroughzoonotictransmissionwithal%casefatalityrate,causingapproximate1y8000victimswor1dwide.EVenthoughSARS-Covtransmissionwascontainedwithinayear,fearremainedthatothercoronavirusesinzoonoticreservoirsmightalsocrossthebarriertohumansandevo1vehumantohumantransmission1ikeSRS-CoVdid.ThisfearbecamereaIityinSeptember2012,whentheMidd1eEastRespiratorySyndromeCoronavirus(MERS-CoV)wasdiscoveredinSaudiArabia,causingseverelowerrespiratOrysymptomsinhunianswithanestiniatedcasefatalItyrateof40%.BecauseofthephylogeneticrelatednessofbothvirusesandsimilaritiesinClinicalsymptomsandpathology,HriskassessmentofMERS-CoVcomparedtoSARS-CoVismade,basedontheknow1edgeavai1ab1eforbothvirusesthusfar.Thisway,abetterpreparednessfornewoutbreaksofMERS-CoVandSARS-CoVCanbCeStabIiShCdandtheriSkOfanCWPandCmiCWiththenewlydiscoveredMERS-CoVcanbeassessed.IntroductionIthasiongbeenknownthalvirusescancrossspeciesbarricrsandadaptfromanimalStohumanstosometimesevolVehumantohuinantransmission,aswasseenforsmallpox,measlesandinfluenza.Thclatter,a1socalIedtheSpanishflu,Causedapandemicbackin1918-19,killing.
